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Article

GLP-1-mediated delivery of the PPAR𝛼/𝛾 dual-agonist Tesaglitazar improves obesity and glucose metabolism in mice

2021-11-30

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<title>Abstract</title> <p>Dual-agonists activating the peroxisome proliferator-activated receptors alpha and gamma (PPAR𝛼/𝛾) have shown beneficial effects on glucose and lipid metabolism in patients with type 2 diabetes, but their development was discontinued due to unfavorable cardiovascular and/or renal effects. Here we report the design and preclinical evaluation of a molecule that covalently links the PPAR...

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Literature Corpus work
a62ceab8-9faf-5ede-9761-7c066344a5d8
DOI
10.21203/rs.3.rs-1081959/v1
Open publication

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GLP-1-mediated delivery of the PPAR𝛼/𝛾 dual-agonist Tesaglitazar improves obesity and glucose metabolism in miceDOI 10.21203/rs.3.rs-1081959/v1
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