Back to search

Article

Blocking chondrocyte hypertrophy in conditional <i>Evc</i> knockout mice does not modify osteoarthritis progression

2021-10-30

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chondrocytes in osteoarthritic (OA) cartilage acquire a hypertrophic-like phenotype, where Hedgehog (Hh) signaling is pivotal. Hh overexpression causes OA-like cartilage lesions, whereas its downregulation prevents articular destruction in mouse models. Mutations in EVC and EVC2 genes disrupt Hh signaling, and are responsible for the Ellis-van Creveld syndrome skeletal dys...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1c8efdfd-39b0-505e-9f5d-7e5b0b75de86
DOI
10.1101/2021.10.29.466392
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Blocking chondrocyte hypertrophy in conditional <i>Evc</i> knockout mice does not modify osteoarthritis progressionDOI 10.1101/2021.10.29.466392
Chondrocyte Hypertrophy in Osteoarthritis: Mechanistic Studies and Models for the Identification of New Therapeutic StrategiesSemantic proximity
Shcbp1 deficiency dampens chondrocyte viability and cartilage ECM homeostasis via disturbing coordination of Akt and Erk signal pathwaysSemantic proximity
Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice.Semantic proximity
Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage modelSemantic proximity
In vivo bone-specific EphB4 overexpression in mice protects both subchondral bone and cartilage during osteoarthritis.Semantic proximity
Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration diseaseSemantic proximity
Hnrnpk protects against osteoarthritis through targeting WWC1 mRNA and inhibiting Hippo signaling pathwaySemantic proximity
MicroRNA‑1 regulates the development of osteoarthritis in a Col2a1‑Cre‑ERT2/GFPfl/fl‑RFP‑miR‑1 mouse model of osteoarthritis through the downregulation of Indian hedgehog expressionSemantic proximity
Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization.Semantic proximity
Activation of β-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects.Semantic proximity
SHIP2 deletion in cartilage does not modulate osteoarthritis in a post-traumatic mouse modelSemantic proximity
Genetic evidence of the regulatory role of parathyroid hormone–related protein in articular chondrocyte maintenance in an experimental mouse modelSemantic proximity
Select a neighboring publication to make it the new centre.