Article
Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice.
Scientific reports - 1 Jul 2020
Lamuedra Ana, Gratal Paula, Calatrava Lucía, Ruiz-Perez Víctor Luis, Largo Raquel, Herrero-Beaumont Gabriel
Abstract excerpt
Osteoarthritis (OA) is a multifactorial joint disease mainly affecting articular cartilage (AC) with a relevant biomechanical component. During endochondral ossification growth plate (GP) chondrocytes arrange in columns. GPs do not ossify in skeletally mature rodents. In neonatal mice, an altered joint loading induces GP chondrocyte disorganization. We aimed to study whether experimental OA involves GP...
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