Article

CRISPR with Transcriptional Readout reveals influenza transcription is modulated by NELF and can precipitate an interferon response

2024-11-15

Abstract excerpt

Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate interferon induction within cells infected by influenza A virus, we developed CRISPR with Transcriptional Readout (CRITR-seq). CRITR-seq is a method linking CRISPR guide sequence to activity at a promoter of interest. Emp...

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Literature Corpus work: 1c8ddc56-399b-59b7-a11d-ea4974c98903
DOI: 10.1101/2024.11.14.623683

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