Article
Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection.
Nature communications - 9 Jan 2020
Li Bo, Clohisey Sara M, Chia Bing Shao, Wang Bo, Cui Ang, Eisenhaure Thomas, Schweitzer Lawrence D, Hoover Paul, Parkinson Nicholas J, Nachshon Aharon, Smith Nikki, Regan Tim, Farr David, Gutmann Michael U, Bukhari Syed Irfan, Law Andrew, Sangesland Maya, Gat-Viks Irit, Digard Paul, Vasudevan Shobha, Lingwood Daniel, Dockrell David H, Doench John G, Baillie J Kenneth, Hacohen Nir
Abstract excerpt
Host dependency factors that are required for influenza A virus infection may serve as therapeutic targets as the virus is less likely to bypass them under drug-mediated selection pressure. Previous attempts to identify host factors have produced largely divergent results, with few overlapping hits across different studies. Here, we perform a genome-wide CRISPR/Cas9 screen and devise a new approach, meta-analysis...
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