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A CRISPR Activation Screen Identifies a Pan-avian Influenza Virus Inhibitory Host Factor

1 Aug 2017

Abstract excerpt

Influenza A virus (IAV) is a pathogen that poses significant risks to human health. It is therefore critical to develop strategies to prevent influenza disease. Many loss-of-function screens have been performed to identify the host proteins required for viral infection. However, there has been no systematic screen to identify the host factors that, when overexpressed, are sufficient to prevent infection. In this...

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PMID: 28813663
DOI: 10.1016/j.celrep.2017.07.060

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