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Motor phenotypes of amyotrophic lateral sclerosis – a three-determinant anatomical classification based on the region of onset, propagation of motor symptoms, and the degree of upper and lower motor neuron dysfunction

2025-03-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In amyotrophic lateral sclerosis (ALS), heterogeneity of motor phenotypes is a fundamental hallmark of the disease. Distinct ALS phenotypes were associated with a different progression and survival. Despite its relevance for clinical practice and research, there is no broader consensus on the classification of ALS phenotypes. <h4>Methods</h4> An expert consensus process for th...

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Literature Corpus work: 1c8c0a17-3e2a-548e-8c9d-a2cc20d24ec6
DOI: 10.1101/2025.03.21.25324256

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