Article

Axonal dying back of upper motor neurons in human ALS

2026-01-12

Abstract excerpt

<title>Abstract</title> <p>Patients with amyotrophic lateral sclerosis (ALS) present with arm, leg, or bulbar weakness with or without spasticity. While genetics plays a clear role in a subset of cases, it cannot explain why symptoms start focally or how upper (UMN) and lower motor neuron (LMN) systems are linked. Here, we examined the clinicopathological relationships between UMN and LMN disease in ten ALS patie...

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Literature Corpus work: f891cc6d-7a12-5484-a915-647cbf7a9c23
DOI: 10.21203/rs.3.rs-8545414/v1

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