Article
Longitudinal respiratory trajectories in motor neuron disease phenotypes: Multiparametric characterization and clinical management.
Respiratory medicine - 1 Apr 2025
Ferraro Pilar M, Mollar Elena, Melissari Laura, Buscema Martina, Bagnoli Emiliano, Cabona Corrado, Gemelli Chiara, Vignolo Manuela, Maranzana Cinzia, Marogna Maura, Ferrera Lorenzo, Beronio Alessandro, De Michelis Claudio, Bergamaschi Valeria, Bragadin Margherita Monti, Brichetto Giampaolo, Braido Fulvio, Rao Fabrizio
Abstract excerpt
BACKGROUND: Motor neuron diseases (MNDs) encompass amyotrophic lateral sclerosis (ALS), pure/predominant upper (pUMN) and lower motor neuron (pLMN) phenotypes. However respiratory studies have mainly focused on bulbar (B-ALS) and spinal (S-ALS) onset ALS, while little is known in other MNDs. In this study we therefore aimed at characterizing baseline and longitudinal patterns of respiratory involvement and their...
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