Article

Proteasome gene expression is controlled by the coordinated functions of multiple transcription factors

2023-04-13

Abstract excerpt

<h4>SUMMARY</h4> Proteasome activity is crucial for cellular integrity, but how tissues adjust proteasome content in response to catabolic stimuli is uncertain. Here, we demonstrate that transcriptional coordination by multiple transcription factors is required to increase proteasome content and activate proteolysis in catabolic states. Using denervated mouse muscle as a model system for accelerated proteolysis...

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Literature Corpus work: 1c7de619-b91d-5f13-996c-aa11f30c52e8
DOI: 10.1101/2023.04.12.536627

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