Article

NRF1/NFE2L1 orchestrates spatiotemporal regulation of protein degradation network in skeletal muscle

2025-10-21

Abstract excerpt

<title>Abstract</title> <p> Skeletal muscle (SkM) relies on precise regulation of protein synthesis and degradation for functional integrity, with the ubiquitin-proteasome system (UPS) as a cornerstone of homeostasis. Nuclear factor (erythroid-derived 2)-like 1 (NFE2L1), a conserved CNC-bZIP transcription factor, integrates redox balance and proteasome gene expression, but its fiber-type-specific roles in SkM re...

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Literature Corpus work: d5820039-ec39-5136-b09a-1e34a3c3eb72
DOI: 10.21203/rs.3.rs-7736640/v1

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