Article

The transcription factors TCF1 and LEF1 drive B-1a cell development, self-renewal, and regulatory function.

2024-01-17

Abstract excerpt

<title>Abstract</title> <p>B-1 cells are abundant in peritoneal and pleural cavities and produce natural and microbial-induced IgM and IgA1–4.CD5+ B-1 cells known as “B-1a” represent the largest source of B cell-derived IL-105,6, an important regulator of inflammation and autoimmunity7. Unlike conventional B cells that are produced daily in the bone marrow, B-1a cells are predominantly generated from foetal precu...

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Literature Corpus work: 1c7bab54-2d36-5d28-bf78-969ab79198b9
DOI: 10.21203/rs.3.rs-3855081/v1

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