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Article

Differentiation and persistence of memory CD8(+) T cells depend on T cell factor 1.

Immunity - 27 Aug 2010

Zhou Xinyuan, Yu Shuyang, Zhao Dong-Mei, Harty John T, Badovinac Vladimir P, Xue Hai-Hui

Abstract excerpt

T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD8(+) T cell responses are unknown. Here we showed that TCF-1 deficiency limited proliferation of CD8(+) effector T cells and impaired their differentiation toward a central memory phenotype. Moreover, TCF-1-deficient...

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Identifiers

PMID: 20727791
DOI: 10.1016/j.immuni.2010.08.002
PMCID: PMC2928475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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