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TCF1 and LEF1 promote B-1a cell homeostasis and regulatory function

20 Aug 2025

Abstract excerpt

Abstract B-1 cells are innate-like immune cells abundant in serosal cavities with antibodies enriched in bacterial recognition, yet their existence in humans has been controversial 1–3 . The CD5 + B-1a subset expresses anti-inflammatory molecules including IL-10, PDL1 and CTLA4 and can be immunoregulatory 4–6 . Unlike conventional B cells that are continuously replenished, B-1a cells are produced early in life...

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PMID: 40836098
DOI: 10.1038/s41586-025-09421-0

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