Article

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

2020-05-04

Abstract excerpt

Prime editing (PE) is a versatile genome editing technology, but design of the required guide RNAs is more complex than for standard CRISPR-based nucleases or base editors. Here we describe PrimeDesign, a user-friendly, end-to-end web application and command-line tool for the design of PE experiments. PrimeDesign can be used for single and combination editing applications, as well as genome-wide and saturation mut...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2058e62b-5ebd-56bd-9d19-82defdcef83c
DOI: 10.1101/2020.05.04.077750

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

PrimeDesign software for rapid and simplified design of prime editing guide RNAsDOI 10.1101/2020.05.04.077750Read

PrimeDesign software for rapid and simplified design of prime editing guide RNAs.Semantic proximity Read

PrimeDesign software for rapid and simplified design of prime editing guide RNAsSemantic proximity Read

PE-Designer and PE-Analyzer: web-based design and analysis tools for CRISPR prime editing.Semantic proximity Read

Prime Editing Guide RNA Design Automation Using PINE-CONE.Semantic proximity Read

Automated design of CRISPR prime editors for thousands of human pathogenic variantsSemantic proximity Read

DNA Prime Editing: A New CRISPR-Based Method to Correct Most Disease-Causing Mutations.Semantic proximity Read

Prime editing: current advances and therapeutic opportunities in human diseases.Semantic proximity Read

SynDesign: web-based prime editing guide RNA design and evaluation tool for saturation genome editing.Semantic proximity Read

OPED: an optimal prime editing guide RNA designer based on deep learning and transfer learningSemantic proximity Read

Predicting prime editing efficiency and product purity by deep learning.Semantic proximity Read

Prime Editing Driven Functional Genomics: Bridging Genotype to Phenotype in the Post-Genomic Era.Semantic proximity Read

Prime Editing Exhibits Limited Genome-Wide Off-Target Effects in Cellular and Embryonic Gene Editing.Semantic proximity Read