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Clinical Impact of Immune Checkpoint Inhibitor (ICI) Response, DNA Damage Repair (DDR) Gene Mutations and Immune-Cell Infiltration in Metastatic Melanoma Subtypes.

Medical sciences (Basel, Switzerland) - 24 May 2022

Andrieu Charlotte, McNamee Niamh, Larkin Anne-Marie, Maguire Alanna, Menon Roopika, Mueller-Eisert Judith, Horgan Noel, Kennedy Susan, Gullo Giuseppe, Crown John, Walsh Naomi

Abstract excerpt

Molecular and histopathological analysis of melanoma subtypes has revealed distinct epidemiological, genetic, and clinical features. However, immunotherapy for advanced metastatic melanoma patients does not differ based on subtype. Response to immune checkpoint inhibitors (ICI) has been shown to vary, therefore, predictive biomarkers are needed in the design of precision treatments. Targeted sequencing and...

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DNA Damage
Immune Checkpoint Inhibitors
Melanoma
Melanoma, Cutaneous Malignant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Second Primary

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PMID: 35736346
DOI: 10.3390/medsci10020026
PMCID: PMC9230974

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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