Article

Multiomics analysis reveals a Type III driven immune response in immunotherapy-induced toxicity in melanoma and identifies potential new therapeutic targets

2023-07-10

Abstract excerpt

<title>Abstract</title> <p>Immune checkpoint inhibitors (ICIs) are standard-of-care for the treatment of advanced melanoma, but their use is limited by immune-related adverse events (irAEs). Proteomic analysis and multiplex cytokine/chemokine assay from serum at baseline and at irAEs onset in 82 patients indicated aberrant T-cell activity with differential expression of Type I and III immune signatures. This was...

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Literature Corpus work: bd04e607-00c3-596f-ba19-234a12c870c8
DOI: 10.21203/rs.3.rs-3062506/v1

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