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Article

Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockade

2020-12-21

Abstract excerpt

<h4>Abstract/Summary</h4> We aimed to characterize immunological features of melanoma patients treated with PD-1 blockade using tumor transcriptomic datasets. Response-dependent and response-independent predictors based on biological knowledge were investigated. Domain knowledge-driven regression-based analysis identified CEACAM1, CD40, B7-H3 , and CD112 as key genes that determine the melanoma immune status. W...

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Identifiers and source

Literature Corpus work
1c104cac-2cbe-5985-8449-83b62633d922
DOI
10.1101/2020.12.20.397000
Open publication

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Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockadeDOI 10.1101/2020.12.20.397000
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