Article

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors

2022-12-11

Abstract excerpt

The mechanism by which ICI (immune checkpoint inhibitor) induce durable antitumor T cell activity remains inadequately defined. Tumors from melanoma patients who responded to ICI or MAPK pathway inhibitors (MAPKi) therapy generally displayed increased T cell infiltration and interferon gamma (IFNγ) pathway activation. Yet, the rate of durable tumor control after ICI is almost twice that of MAPKi. Comparing the tra...

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Identifiers and source

Literature Corpus work: d856d753-4872-5022-b06a-9592d515cf7e
DOI: 10.1101/2022.12.08.519660

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