Article

Highly-selective μ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model

2020-03-02

Abstract excerpt

<title>Abstract</title> <p>Objectives Dopamine-replacement utilizing L-DOPA is still the mainstay treatment for Parkinson’s disease (PD), but often leads to development of L-DOPA-induced dyskinesia (LID), which can be as debilitating as the motor deficits. There is currently no satisfactory pharmacological adjunct therapy. The endogenous opioid peptides enkephalin and dynorphin are important co-transmitters in th...

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Literature Corpus work: 1c59b167-2bf1-5605-978f-fc959d4c9814
DOI: 10.21203/rs.2.21906/v3

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