The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model.

doi:10.1016/0014-2999(94)90103-1

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Article

The novel selective and silent 5-HT1A receptor antagonist (+)-WAY-100135 aggravates dystonic movements in a mutant hamster model.

European journal of pharmacology - 1 Apr 1994

Löscher W, Richter A

Abstract excerpt

Several clinical and experimental findings suggest that abnormal serotonin (5-HT) function may be involved in movement disorders such as dystonia, and it was proposed that selective 5-HT1A receptor antagonists may be of benefit in treating such disorders. In the present study, the novel, highly s...

Topics

8-Hydroxy-2-(di-n-propylamino)tetralin
Animals
Behavior, Animal
Cricetinae
Dystonia
Female
Male
Mesocricetus
Mutation
Piperazines
Serotonin Antagonists

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