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Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

9 Dec 2014

Abstract excerpt

Classical Hodgkin lymphoma (cHL) is characterized by sparsely distributed Hodgkin and Reed-Sternberg (HRS) cells amid reactive host background, complicating the acquisition of neoplastic DNA without extensive background contamination. We overcame this limitation by using flow-sorted HRS and intratumor T cells and optimized low-input exome sequencing of 10 patient samples to reveal alterations in genes involved in...

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PMID: 25488972
DOI: 10.1182/blood-2014-11-610436

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