Article

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3Kγ <sub>RBD</sub> Frequently Generate Affinity Increases

2026-05-06

Abstract excerpt

The three conventional isoforms of the Ras G-protein (H-, K-, N-Ras) function as molecular on-off switches that regulate a wide array of signaling pathways, including the Ras-PI3K-PIP 3 -PDK1-AKT pathway that is central to innate immunity and normal cell growth, and is dysregulated in many disease states. Activation of the pathway by Ras requires adequate Ras-PI3K binding affinity. Here we focus on the interface...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c3bd5eb-0eb3-57b0-98da-dfae5595f614
DOI: 10.64898/2026.05.01.722339

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3Kγ <sub>RBD</sub> Frequently Generate Affinity IncreasesDOI 10.64898/2026.05.01.722339Read

COSMIC-Linked Ras Mutations at the Interface Between H-Ras and PI3KγRBD Frequently Generate Affinity Increases.Semantic proximity Read

A cancer-associated K-RAS mutant that preferentially binds GDP displays gain-of-function and atypical signalingSemantic proximity Read

The Ins and Outs of RAS Effector Complexes.Semantic proximity Read

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.Semantic proximity Read

Oncogenic G12D mutation alters local conformations and dynamics of K-RasSemantic proximity Read

The K-Ras, N-Ras, and H-Ras Isoforms: Unique Conformational Preferences and Implications for Targeting Oncogenic Mutants.Semantic proximity Read

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activationSemantic proximity Read

Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.Semantic proximity Read

K-Ras G-domain binding with signaling lipid phosphoinositides: PIP2 association, orientation, functionSemantic proximity Read

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.Semantic proximity Read

Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-RasSemantic proximity Read

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.Semantic proximity Read