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Article

Revisiting RAS family GTPase signaling: effector selectivity and oncogenic bypass.

The Biochemical journal - 6 May 2026

Simanshu Dhirendra K, McCormick Frank

Abstract excerpt

Distinct effector-binding preferences among RAS family GTPases challenge the longstanding view that canonical RAS proteins uniformly bind and activate RAF, PI3Kα, RalGDS, and other downstream effectors. Quantitative binding data, supported by structural insights into effector recognition, instead reveal a division of labor: the canonical RAS subfamily (KRAS, HRAS, NRAS) binds RAF kinases with high affinity, the...

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HRAS gene
KRAS gene
NRAS gene
Mutation
raf Kinases
ras Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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Identifiers

PMID: 42017331
DOI: 10.1042/BCJ20250142
PMCID: PMC13142924

Genes

KRAS
MRAS
RAP1A
RRAS2
HRAS
NRAS
RAP1B
RRAS

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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