Article

Oncogenic G12D mutation alters local conformations and dynamics of K-Ras

2017-08-19

Abstract excerpt

K-Ras is the most frequently mutated oncoprotein in human cancers, and G12D is its most prevalent mutation. To understand how G12D mutation impacts K-Ras function, we need to understand how it alters the regulation of its dynamics. Here, we present local changes in K-Ras structure, conformation and dynamics upon G12D mutation, from long-timescale Molecular Dynamics simulations of active (GTP-bound) and inactive (G...

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Literature Corpus work: 50a502bf-5daf-5df5-89d0-a8052184ceb7
DOI: 10.1101/178483

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