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Article

Oncogenic K-Ras4B Dimerization Enhances Downstream Mitogen-activated Protein Kinase Signaling.

Journal of molecular biology - 14 Feb 2020

Muratcioglu Serena, Aydin Cihan, Odabasi Ezgi, Ozdemir E Sila, Firat-Karalar Elif Nur, Jang Hyunbum, Tsai Chung-Jung, Nussinov Ruth, Kavakli Ibrahim Halil, Gursoy Attila, Keskin Ozlem

Abstract excerpt

Ras recruits and activates effectors that transmit receptor-initiated signals. Monomeric Ras can bind Raf; however, Raf's activation requires dimerization, which can be facilitated by Ras dimerization. Previously, we showed that active K-Ras4B dimerizes in silico and in vitro through two major interfaces: (i) β-interface, mapped to Switch I and effector-binding regions, (ii) α-interface at the allosteric lobe....

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Share to Fluorescence Resonance Energy Transfer
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

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Source

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Identifiers

PMID: 31931009
DOI: 10.1016/j.jmb.2020.01.002
PMCID: PMC8533050

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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