Article

Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras

2020-03-29

Abstract excerpt

<h4>ABSTRACT</h4> K-Ras is the most frequently mutated protein in human cancers. However, until very recently, its oncogenic mutants were viewed as undruggable. To develop inhibitors that directly target oncogenic K-Ras mutants, we need to understand both their mutant-specific and pan-mutant dynamics and conformations. Recently, we have investigated how the most frequently observed K-Ras mutation in cancer patien...

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Literature Corpus work: afe4d9f8-3829-5d4d-9959-94fc2c69a14d
DOI: 10.1101/2020.03.26.010710

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