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Article

Structure and mechanism of NALCN-FAM155A-UNC79-UNC80 channel complex.

Nature communications - 12 May 2022

Kang Yunlu, Chen Lei

Abstract excerpt

NALCN channel mediates sodium leak currents and is important for maintaining proper resting membrane potential. NALCN and FAM155A form the core complex of the channel, the activity of which essentially depends on the presence of both UNC79 and UNC80, two auxiliary proteins. NALCN, FAM155A, UNC79, and UNC80 co-assemble into a large hetero-tetrameric channel complex. Genetic mutations of NALCN channel components...

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Identifiers

PMID: 35550517
DOI: 10.1038/s41467-022-30403-7
PMCID: PMC9098444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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