COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

doi:10.1091/mbc.E14-06-1073

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Article

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Molecular biology of the cell - 1 Jan 2015

Phillips-Krawczak Christine A, Singla Amika, Starokadomskyy Petro, Deng Zhihui, Osborne Douglas G, Li Haiying, Dick Christopher J, Gomez Timothy S, Koenecke Megan, Zhang Jin-San, Dai Haiming, Sifuentes-Dominguez Luis F, Geng Linda N, Kaufmann Scott H, Hein Marco Y, Wallis Mathew, McGaughran Julie, Gecz Jozef, Sluis Bart van de, Billadeau Daniel D, Burstein Ezra

Abstract excerpt

COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex interacts with the multisubunit WASH complex, an evolutionarily conserved system, which is required for endosomal...

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Identifiers

PMID: 25355947
DOI: 10.1091/mbc.E14-06-1073
PMCID: PMC4279232

Genes

CCDC22
COMMD1
CCDC93

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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