Article
Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages.
Cell reports - 11 Oct 2016
Van den Bossche Jan, Baardman Jeroen, Otto Natasja A, van der Velden Saskia, Neele Annette E, van den Berg Susan M, Luque-Martin Rosario, Chen Hung-Jen, Boshuizen Marieke C S, Ahmed Mohamed, Hoeksema Marten A, de Vos Alex F, de Winther Menno P J
Abstract excerpt
Macrophages are innate immune cells that adopt diverse activation states in response to their microenvironment. Editing macrophage activation to dampen inflammatory diseases by promoting the repolarization of inflammatory (M1) macrophages to anti-inflammatory (M2) macrophages is of high interest. Here, we find that mouse and human M1 macrophages fail to convert into M2 cells upon IL-4 exposure in vitro and...
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