Article

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

2020-08-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> SARS-CoV-2 entry into host cells is facilitated by endogenous and exogenous proteases that proteolytically activate the spike glycoprotein and antiproteases inhibiting this process. Understanding the key actors in viral entry is crucial for advancing knowledge of virus tropism, pathogenesis, and potential therapeutic targets. <h4>Objectives</h4> We aimed to investigate the r...

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Literature Corpus work: 1c2d99d5-0b9a-5ee8-8e49-4d832959994c
DOI: 10.1101/2020.08.14.248880

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