Article

Rapid SARS-CoV-2 Adaptation to Available Cellular Proteases

2020-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Since the pandemic spread of SARS-CoV-2, the virus has exhibited remarkable genome stability, but recent emergence of novel variants show virus evolution potential. Here we show that SARS-CoV-2 rapidly adapts to Vero E6 cells that leads to loss of furin cleavage motif in spike protein. The adaptation is achieved by asymptotic expansion of minor virus subpopulations to dominant genotype, but wild...

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Literature Corpus work: e4e46aaf-2da6-56d7-ba09-0865f2303a1c
DOI: 10.1101/2020.08.10.241414

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