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SARS-CoV-2 mechanisms of cell tropism in various organs considering host factors

1 Feb 2024

Abstract excerpt

A critical step in the drug design for SARS-CoV-2 is to discover its molecular targets. This study comprehensively reviewed the molecular mechanisms of SARS-CoV-2, exploring host cell tropism and interaction targets crucial for cell entry. The findings revealed that beyond ACE2 as the primary entry receptor, alternative receptors, co-receptors, and several proteases such as TMPRSS2, Furin, Cathepsin L, and ADAM...

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PMID: 38420467
DOI: 10.1016/j.heliyon.2024.e26577

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