Article

Impact of human CD8+ T cell senescence on<sup>89</sup>Zr radiolabelling and homing properties

2023-02-07

Abstract excerpt

The ability of CD8+ T cells to protect against infection and malignant transformation diminishes with age. Novel means to assess cellular functional deficits in vivo are being made available such as total-body positron emission tomography (PET) and radiotracers with long half-lives. Here, we determined radiolabeled human CD8+ T cells isolated from young and old individuals with zirconium-89 ( 89 Zr) and assessed t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c268997-5e60-5e94-b869-50571fbf1bba
DOI: 10.1101/2023.02.04.23285413

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of human CD8+ T cell senescence on<sup>89</sup>Zr radiolabelling and homing propertiesDOI 10.1101/2023.02.04.23285413Read

Impact of human CD8+ T cell senescence on 89Zr radiolabelling and homing propertiesSemantic proximity Read

Direct measurement of T cell subset kinetics in vivo in elderly men and women.Semantic proximity Read

Properties of end-stage human T cells defined by CD45RA re-expressionSemantic proximity Read

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells.Semantic proximity Read

<i>In vivo</i> tracking of <i>ex vivo</i> generated <sup>89</sup> Zr-oxine labeled plasma cells by PET in a non-human primate modelSemantic proximity Read

Characterization of Chimeric Antigen Receptor Modified T Cells Expressing scFv-IL-13Rα2 after Radiolabeling with 89Zirconium Oxine for PET ImagingSemantic proximity Read

An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic EfficacySemantic proximity Read

Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult ThymusSemantic proximity Read

Resilient Biophysical Phenotype of Memory CD4 + T Cells in Long-Lived Mice.Semantic proximity Read

Specific Imaging of CD8+ T-Cell Dynamics with a Nanobody Radiotracer against Human CD8βSemantic proximity Read

Thymic CD8+ T Cell Production Strongly Influences Tumor Antigen Recognition and Age-Dependent Glioma MortalitySemantic proximity Read

Human Stem Cell-like Memory T Cells Are Maintained in a State of Dynamic FluxSemantic proximity Read