Article
Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells.
Cell reports - 19 Jun 2018
Quinn Kylie M, Fox Annette, Harland Kim L, Russ Brendan E, Li Jasmine, Nguyen Thi H O, Loh Liyen, Olshanksy Moshe, Naeem Haroon, Tsyganov Kirill, Wiede Florian, Webster Rosela, Blyth Chantelle, Sng Xavier Y X, Tiganis Tony, Powell David, Doherty Peter C, Turner Stephen J, Kedzierska Katherine, La Gruta Nicole L
Abstract excerpt
Age-associated decreases in primary CD8+ T cell responses occur, in part, due to direct effects on naive CD8+ T cells to reduce intrinsic functionality, but the precise nature of this defect remains undefined. Aging also causes accumulation of antigen-naive but semi-differentiated "virtual memory" (TVM) cells, but their contribution to age-related functional decline is unclear. Here, we show that TVM cells are...
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