Article

An Aged Microenvironment Increases CAR T Cell Cytotoxicity but Impairs Therapeutic Efficacy

2025-05-05

Abstract excerpt

<h4>Background</h4> Cancer disproportionately affects the elderly, who are often less able to tolerate traditional cytotoxic therapies, and may benefit from T cell–based immunotherapies. However, studies evaluating the efficacy of T cell immunotherapy in aged mice are limited and yield inconsistent results, while clinical data are largely retrospective. <h4>Methods</h4> Here, we used a murine model of Chimeric A...

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Literature Corpus work: ec2ee20c-8dca-5cc6-82d9-f0791a13f8c8
DOI: 10.1101/2025.05.04.652106

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