Article
Direct measurement of T cell subset kinetics in vivo in elderly men and women.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2004
Wallace Diana L, Zhang Yan, Ghattas Hala, Worth Andrew, Irvine Andrew, Bennett Andrea R, Griffin George E, Beverley Peter C L, Tough David F, Macallan Derek C
Abstract excerpt
The age-associated decline in immunocompetence is paralleled by changes in the proportions of PBL subpopulations. In turn, the size and composition of the peripheral lymphocyte pool is determined by input from the thymus and bone marrow and by the balance of proliferation and death in each lymphocyte subpopulation. We compared the kinetics of lymphocyte subtypes in young (seven of eight CMV seronegative) and...
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