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Article

Properties of end-stage human T cells defined by CD45RA re-expression

1 May 2012

Abstract excerpt

Persistent viral infections, inflammatory syndromes and ageing all induce the accumulation of highly differentiated CD45RA re-expressing memory T cells. These cells increase during ageing, especially in individuals who are infected with cytomegalovirus (CMV). These cells have decreased proliferative capacity, increased activation of senescence signalling pathways and greater susceptibility to apoptosis in vitro....

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PMID: 22554789
DOI: 10.1016/j.coi.2012.04.001

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