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Characterization of Chimeric Antigen Receptor Modified T Cells Expressing scFv-IL-13Rα2 after Radiolabeling with 89Zirconium Oxine for PET Imaging

2023-01-13

Abstract excerpt

<title>Abstract</title> <p>Background Chimeric antigen receptor (CAR) T cell therapy is an exciting cell-based cancer immunotherapy. Unfortunately, CAR-T cell therapy is associated with serious toxicities such as cytokine release syndrome (CRS) and neurotoxicity. The mechanism of these serious adverse events (SAEs) and how homing, distribution and retention of CAR-T cells contribute to toxicities is not fully un...

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Literature Corpus work: bf5dd998-0734-58d2-8446-599001b08c28
DOI: 10.21203/rs.3.rs-2242559/v1

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