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Article

Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics.

Scientific reports - 11 Nov 2021

Behzadi Arvin, Pujol-Calderón Fani, Tjust Anton E, Wuolikainen Anna, Höglund Kina, Forsberg Karin, Portelius Erik, Blennow Kaj, Zetterberg Henrik, Andersen Peter Munch

Abstract excerpt

Delayed diagnosis and misdiagnosis are frequent in people with amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease (MND). Neurofilament light chain (NFL) and phosphorylated neurofilament heavy chain (pNFH) are elevated in ALS patients. We retrospectively quantified cerebrospinal fluid (CSF) NFL, CSF pNFH and plasma NFL in stored samples that were collected at the diagnostic work-up...

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Identifiers

PMID: 34764380
DOI: 10.1038/s41598-021-01499-6
PMCID: PMC8585882

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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