Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study.

doi:10.1016/S1474-4422(20)30137-X

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Article

Plasma neurofilament light chain in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional and longitudinal cohort study.

The Lancet. Neurology - 1 Jun 2020

Quiroz Yakeel T, Zetterberg Henrik, Reiman Eric M, Chen Yinghua, Su Yi, Fox-Fuller Joshua T, Garcia Gloria, Villegas Andres, Sepulveda-Falla Diego, Villada Marina, Arboleda-Velasquez Joseph F, Guzmán-Vélez Edmarie, Vila-Castelar Clara, Gordon Brian A, Schultz Stephanie A, Protas Hillary D, Ghisays Valentina, Giraldo Margarita, Tirado Victoria, Baena Ana, Munoz Claudia, Rios-Romenets Silvia, Tariot Pierre N, Blennow Kaj, Lopera Francisco

Abstract excerpt

BACKGROUND: Neurofilament light chain (NfL) is a promising biomarker of active axonal injury and neuronal degeneration. We aimed to characterise cross-sectional and longitudinal plasma NfL measurements and determine the age at which NfL concentrations begin to differentiate between carriers of the presenilin 1 (PSEN1) E280A (Glu280Ala) mutation and age-matched non-carriers from the Colombian autosomal dominant...

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PMID: 32470423
DOI: 10.1016/S1474-4422(20)30137-X
PMCID: PMC7417082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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