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Neurofilaments in pre-symptomatic ALS and the impact of genotype

21 Aug 2019

Abstract excerpt

Objective. To evaluate serum and cerebrospinal fluid (CSF) levels of phosphorylated neurofilament heavy (pNfH), and to compare these to levels of neurofilament light (NfL), as biomarkers of pre-symptomatic ALS. Design. The study population includes 34 controls, 79 individuals at-risk for ALS, 22 ALS patients, and 14 phenoconverters. At-risk individuals are enrolled through Pre-Symptomatic Familial ALS (Pre-fALS),...

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PMID: 31432691
DOI: 10.1080/21678421.2019.1646769

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