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Article

Diagnostic and Prognostic Biomarkers in Amyotrophic Lateral Sclerosis: Neurofilament Light Chain Levels in Definite Subtypes of Disease.

JAMA neurology - 1 May 2017

Gaiani Alessandra, Martinelli Ilaria, Bello Luca, Querin Giorgia, Puthenparampil Marco, Ruggero Susanna, Toffanin Elisabetta, Cagnin Annachiara, Briani Chiara, Pegoraro Elena, Sorarù Gianni

Abstract excerpt

Importance: A clearer definition of the role of neurofilament light chain (NFL) as a biomarker in amyotrophic lateral sclerosis (ALS) is needed. Objectives: To assess the ability of NFL to serve as a diagnostic biomarker in ALS and the prognostic value of cerebrospinal fluid NFL in patients with ALS. Design, Setting, and Participants: In this single-center, retrospective, longitudinal study, disease progression...

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Identifiers

PMID: 28264096
DOI: 10.1001/jamaneurol.2016.5398
PMCID: PMC5822207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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