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Article

Transcription factor regulation of ribosomal RNA in hematopoiesis

3 Apr 2024

Abstract excerpt

PURPOSE OF REVIEW: Ribosomal RNAs (rRNAs) are transcribed within nucleoli from rDNA repeats by RNA Polymerase I (Pol I). There is variation in rRNA transcription rates across the hematopoietic tree, and leukemic blast cells have prominent nucleoli, indicating abundant ribosome biogenesis. The mechanisms underlying these variations are poorly understood. The purpose of this review is to summarize findings of rDNA...

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PMID: 38568093
DOI: 10.1097/moh.0000000000000816

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