Article

Tom1p ubiquitin ligase structure, interaction with Spt6p, and function in maintaining normal transcript levels and the stability of chromatin in promoters

2024-07-08

Abstract excerpt

<h4>ABSTRACT</h4> Phosphorylation-dependent binding of the S. cerevisiae Spt6p tSH2 domain (Spt6p tSH2 ) to the Rbp1p subunit of RNA polymerase II supports efficient transcription. Here, we report that Spt6p tSH2 also binds the HECT-family E3 ubiquitin ligase Tom1p, a homolog of human HUWE1. Tom1p/HUWE1 have been implicated in targeting many small basic proteins for degradation, including excess ribosomal subu...

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Literature Corpus work: a1a67c99-4e4a-5b9c-b0f8-7ebc6d9fe5af
DOI: 10.1101/2024.07.08.601072

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