Article

SUMO-mediated regulation of a H3K4me3 reader controls germline development in <i>C. elegans</i>

2024-02-28

Abstract excerpt

ULP-2 is a conserved SUMO protease required for embryonic development in C. elegans . Here we revealed that ULP-2 controls germline development by regulating the PHD-SET domain protein, SET-26. Specifically, the ulp-2 mutant hermaphrodites exhibit increased sterility and progressive elevation in global protein sumoylation. In the progeny of homozygous animals, meiosis is arrested at the diplotene stage and the c...

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Literature Corpus work: 1c050b3b-985e-53c6-bebf-0236c4c68f2f
DOI: 10.1101/2024.02.27.582283

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