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Article

Two<i>C. elegans</i>histone methyltransferases repress<i>lin-3</i>EGF transcription to inhibit vulval development

19 Jul 2007

Abstract excerpt

Studies of Schizosaccharomyces pombe and mammalian cells identified a series of histone modifications that result in transcriptional repression. Lysine 9 of histone H3 (H3K9) is deacetylated by the NuRD complex, methylated by a histone methyltransferase (HMT) and then bound by a chromodomain-containing protein, such as heterochromatin protein 1 (HP1), leading to transcriptional repression. A Caenorhabditis...

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PMID: 17634190
DOI: 10.1242/dev.009373

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