Article

Missense variants in human ACE2 modify binding to SARS-CoV-2 Spike

2021-05-21

Abstract excerpt

SARS-CoV-2 infection begins with the interaction of the SARS-CoV-2 Spike (Spike) and human angiotensin-converting enzyme 2 (ACE2). To explore whether population variants in ACE2 might influence Spike binding and hence infection, we selected 10 ACE2 variants based on affinity predictions and prevalence in gnomAD and measured their affinities for Spike receptor binding domain through surface plasmon resonance (SPR)....

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Literature Corpus work: 1bf531b5-9bad-572b-a40e-2fa2a690e511
DOI: 10.1101/2021.05.21.445118

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