Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

doi:10.1038/s42003-021-02030-3

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Article

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.

Communications biology - 12 Apr 2021

Suryamohan Kushal, Diwanji Devan, Stawiski Eric W, Gupta Ravi, Miersch Shane, Liu Jiang, Chen Chao, Jiang Ying-Ping, Fellouse Frederic A, Sathirapongsasuti J Fah, Albers Patrick K, Deepak Tanneeru, Saberianfar Reza, Ratan Aakrosh, Washburn Gavin, Mis Monika, Santhosh Devi, Somasekar Sneha, Hiranjith G H, Vargas Derek, Mohan Sangeetha, Phalke Sameer, Kuriakose Boney, Antony Aju, Ustav Mart, Schuster Stephan C, Sidhu Sachdev, Junutula Jagath R, Jura Natalia, Seshagiri Somasekar

Abstract excerpt

COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) receptor to invade host cells with ~10-15-fold higher affinity compared to SARS-CoV S-protein, making it highly infectious. Here, we assessed if ACE2 polymorphisms can alter host susceptibility to SARS-CoV-2 by affecting this interaction. We...

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Identifiers

PMID: 33846513
DOI: 10.1038/s42003-021-02030-3
PMCID: PMC8041869

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