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Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2.

Zoological research - 18 Mar 2021

Shu Chuan-Jun, Huang Xuan, Tang Hui-Hao, Mo Ding-Ding, Zhou Jian-Wei, Deng Cheng

Abstract excerpt

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread rapidly worldwide with high rates of transmission and substantial mortality. To date, however, no effective treatments or enough vaccines for COVID-19 are available. The roles of angiotensin converting enzyme 2 (ACE2) and spike protein in the treatment of COVID-19 are major areas of...

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Alleles
Angiotensin-Converting Enzyme 2
COVID-19
Point Mutation
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spike Glycoprotein, Coronavirus

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PMID: 33738989
DOI: 10.24272/j.issn.2095-8137.2020.301
PMCID: PMC7995276

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